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SCH 351125

CAS No. 370893-06-4

SCH 351125 ( SCH-C;SCH351125;Ancriviroc )

Catalog No. M14276 CAS No. 370893-06-4

A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCH 351125
  • Note
    Research use only, not for human use.
  • Brief Description
    A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.
  • Description
    A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor; specifically inhibits HIV-1 infection mediated by CCR5 in U-87 astroglioma cells but has no effect on infection of CXCR4-expressing cells; has broad and potent antiviral activity in vitro against primary HIV-1 isolates with IC50 of 0.4-9 nM; strongly inhibits the replication of an R5-using HIV-1 isolate in SCID-hu Thy/Liv mice; has a favorable pharmacokinetic profile and orally bioavailable.
  • Synonyms
    SCH-C;SCH351125;Ancriviroc
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    370893-06-4
  • Formula Weight
    557.53
  • Molecular Formula
    C28H37BrN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCON=C(C1CCN(CC1)C2(CCN(CC2)C(=O)C3=C(C=C[N+](=C3C)[O-])C)C)C4=CC=C(C=C4)Br
  • Chemical Name
    (Z)-3-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-methyl-[1,4'-bipiperidine]-1'-carbonyl)-2,4-dimethylpyridine 1-oxide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Strizki JM, et al. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12718-23.
2. Palani A, et al. J Med Chem. 2001 Oct 11;44(21):3339-42.
3. Tremblay CL, et al. Antimicrob Agents Chemother. 2002 May;46(5):1336-9.
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