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SCH 351125
CAS No. 370893-06-4
SCH 351125 ( SCH-C;SCH351125;Ancriviroc )
Catalog No. M14276 CAS No. 370893-06-4
A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 435 | Get Quote |
|
| 50MG | 1341 | Get Quote |
|
| 100MG | 1773 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameSCH 351125
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.
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DescriptionA small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor; specifically inhibits HIV-1 infection mediated by CCR5 in U-87 astroglioma cells but has no effect on infection of CXCR4-expressing cells; has broad and potent antiviral activity in vitro against primary HIV-1 isolates with IC50 of 0.4-9 nM; strongly inhibits the replication of an R5-using HIV-1 isolate in SCID-hu Thy/Liv mice; has a favorable pharmacokinetic profile and orally bioavailable.
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SynonymsSCH-C;SCH351125;Ancriviroc
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV
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Research Area——
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Indication——
Chemical Information
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CAS Number370893-06-4
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Formula Weight557.53
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Molecular FormulaC28H37BrN4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCCON=C(C1CCN(CC1)C2(CCN(CC2)C(=O)C3=C(C=C[N+](=C3C)[O-])C)C)C4=CC=C(C=C4)Br
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Chemical Name(Z)-3-(4-((4-bromophenyl)(ethoxyimino)methyl)-4'-methyl-[1,4'-bipiperidine]-1'-carbonyl)-2,4-dimethylpyridine 1-oxide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
2. Palani A, et al. J Med Chem. 2001 Oct 11;44(21):3339-42.
3. Tremblay CL, et al. Antimicrob Agents Chemother. 2002 May;46(5):1336-9.
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3-Deazaadenosine hyd...
3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 μM). It has anti-inflammatory, anti-proliferative, and anti-HIV activity.3-Deazaadenosine shows the anti-HIV effect and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018, IC50s: 0.15 and 0.20 μM).
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Terameprocol
Terameprocol is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity.
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Peptide T
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a synthetic octapeptide whose possible mechanism of action is the competitive inhibition of gp120 to the CD4 receptor as well as binding to vasointestinal peptide receptors and inhibiting cytokine action.
